ArrayScan HCS Thermo Integrated High Content Screening System

The Thermo/Cellomics ArrayScan HCS System is an automated system for screening arrays of fluorescently labeled cells within a microplate. It is designed for performing quantitative multicolor fluorescence intensity and morphological measurements of cells labeled with one or more fluorescent dyes. Measurements are made on a cell-by-cell or field-by-field basis within each well. The ArrayScan HCS Reader uses fluorescence microscopy and image digitization techniques, as well as proprietary software, to acquire and process images as digital information. The ArrayScan HCS System images cells within the wells of standard microplates. In combination with the HitKit series of reagent kits that label specific cellular constituents, the ArrayScan software automatically measures the multiparametric effects of new drug candidates in the highly complex environment of the cell.

The unique optical path of the ArrayScan HCS System is optimized for performing rapid automated scans in clear-bottom microplates. The system automatically focuses on a field of fluorescently labeled cells and acquires images at each selected channel. The ArrayScan software identifies and measures individual features and structures within each cell in a field of cells, so that hundreds of cells are analyzed in parallel. The software then tabulates and presents the results in user-defined formats automatically. All of the raw data, including images of individual cells, are archived and available for inspection and analysis.

The ArrayScan HCS software provides for multicolor imaging, automated cell-based image analysis, and data management for archiving, analysis and creation of reports. An intuitive, graphical user interface guides you through image acquisition, image analysis, data review and data reporting.

The system fits easily into your current laboratory and permits growth into higher-density array formats.